Phylogeny of East Asian mtDNA

Am. J. Hum. Genet., 73:000, 2003

Phylogeny of East Asian Mitochondrial DNA Lineages Inferred from Complete Sequences

Qing-Peng Kong et al.

The now-emerging mitochondrial DNA (mtDNA) population genomics provides information for reconstructing a well-resolved mtDNA phylogeny and for discerning the phylogenetic status of the subcontinentally specific haplogroups. Although several major East Asian mtDNA haplogroups have been identified in studies elsewhere, some of the most basal haplogroups, as well as numerous minor subhaplogroups, were not yet determined or fully characterized. To fill the lacunae, we selected 48 mtDNAs from >2,000 samples across China for complete sequencing that cover virtually all (sub)haplogroups discernible to date in East Asia. This East Asian mtDNA phylogeny can henceforth serve as a solid basis for phylogeographic analyses of mtDNAs, as well as for studies of mitochondrial diseases in East and Southeast Asia.

...

"Since there is no positive evidence yet that the East Asian haplogroups would share any mutations with the West Eurasian or South Asian haplogroups other than those defining M, N, and R (Kivisild et al. 2002), it seems that the first modern humans carried exactly the root haplotypes of the three Eurasian macrohaplogroups into Southeast Asia. The founder age for the three root haplotypes that are based on the set of 48 coding-region sequences is then estimated as 65.4 ± 3.8 ky"

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Posted by Dienekes at July 19, 2003 04:45 AM | PermaLink